Here's a series of exposures of the moon using the f11 rule. Note effect on noise / compression.
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1/90 f11 ISO 100
45.6 KB (46,754 bytes) |
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1/180 f11 ISO 200
50.7 KB (51,933 bytes) |
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1/350 f11 ISO 400
55.5 KB (56,921 bytes) |
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1/750 f11 ISO 800
61.3 KB (62,856 bytes) |
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1/1500
f11 ISO 1600
74.5 KB (76,337 bytes) |

This creature was taken at 1/4000, f4.0, ISO 400, 100mm lens ( really a 160mm lens). This is a 1:1 crop of the High res. jpeg.
Note the noise.

ISO 400, RAW mode

50mm lens and bee, scaled

50mm lens and bee, cropped !:!